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HOME Publications

HOME core outcome set (domains)

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting
Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H.
Allergy 2012: Sep;67(9):1111-1117; doi 10.1111/j.1398-9995.2012.02874.x (Abstract Link)

Core outcome domains for controlled trials and clinical recordkeeping in eczema: International multiperspective Delphi consensus process
Schmitt J, Langan S, Stamm T and Williams HC, on behalf of the Harmonizing Outcome Measurements in Eczema (HOME) Delphi panel.
J Invest Dermatol. 2011 Mar;131(3):623-30. doi: 10.1038/jid.2010.303 ( Abstract Link)

 
Home core outcome instrument consensus statements

POEM a core instrument to measure symptoms in clinical trials: a HOME statement
Spuls PI, Gerbens LA, Simpson E, Apfelbacher CJ, Chalmers JR, Thomas KS, Prinsen CA, von Kobyletzki LB, Singh JA, Williams HC, Schmitt J; HOME initiative collaborators.
Br J Dermatol. 2017 Apr;176(4):979-984. doi:10.1111\bjd.15179 (Abstract Link)

The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials
Schmitt J, Spuls PI, thomas KS, Simpson E, Furue M, Deckert S, Dohil M, Apfelbacher C, Singh JA, Chalmers J, Williams HC; HOME initiative collaborators.
J Allergy Clin Immunol 2014 Oct;134(4):800-7. doi: 10.1016/j.jaci.2014.07.043 ( Abstract Link)
 
HOME Roadmap

The Harmonising Outcomes for Eczema (HOME) roadmap: A methodological framework to develop core sets of outcome measurements in dermatology
Schmitt J, Apfelbacher C, Spuls PI, Thomas KS, Simpson EL, Furue M, Chalmers J, Williams HC.
J Invest Dermatol 2015 Jan;135(1):24-30. doi: 10.1038/jid.2014.320 (Abstract Link)

 
HOME Meeting reports

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
Chalmers JR, Thomas KS, Apfelbacher C, Williams HC, Prinsen CA, Spuls PI, Simpson E, Gerbens LAA, Boers M, Barbarot S, Stalder JF, Abuabara K, Aoki V, Ardeleanu M, Armstrong J, Bang B, Berents TL, Burton T, Butler L, Chubachi T, Cresswell-Melville A, DeLozier A, Eckert L, Eichenfield L, Flohr C, Futamura M, Gadkari A, Gjerde ES, van Halewijn KF, Hawkes C, Howells L, Howie L, Humphreys R, Ishii HA, Kataoka Y, Katayama I, Kouwenhoven W, Langan SM, Leshem YA, Merhand S, Mina-Osorio P, Murota H, Nakahara T, Nunes FP, Nygaard U, Nygardas M, Ohya Y, Ono E, Rehbinder E, Rogers NK, Romeijn GLE, Schuttelaar MLA, Sears AV, Simpson, MA, Singh JA, Srour J, Stuart B, Svensson A, Talmo G, Talmo H, Teixeira HD, Thyssen JP, Todd G, Torchet F, Volke A, von Kobyletzki L, Weisshaar E, Wollenberg A, Zaniboni M
Br J Dermatol 2018 Apr 19. doi: 10.1111/bjd.16543 [Epub ahead of print] (Abstract link)

Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
Chalmers JR, Simpson E, Apfelbacher CJ, Thomas KS, von Kobyletzki L, Schmitt J, Singh JA, Svensson Å, Williams H, Abuabara K, Aoki V, Ardeleanu M, Awici-Rasmussen M, Barbarot S, Berents TL, Block J, Bragg A, Burton T, Bjerring Clemmensen KK, Creswell-Melville A, Dinesen M, Drucker A, Eckert L, Flohr C, Garg M, Gerbens LA, Graff AL, Hanifin, Heinl, Humphreys R, Ishii HA, Kataoka Y, Leshem Y, Marquort B, Massuel MA, Merhand S, Mizutani H, Murota H, Murrell DF, Nakahara T, Nasr I, Nograles K, Ohya Y, Osterloh I, Pander J, Prinsen C, Purkins L, Ridd M, Sach T, Schuttelaar ML, Shindo S, Smirnova, Sulzer A, Synnøve Gjerde E, Takaoka R, Vestby Talmo H, Tauber M, Torchet F, Volke A, Wahlgren CF, Weidinger S, Weisshaar E, Wollenberg A, Yamaga K, Zhao CY, Spuls PI.
Br J Dermatol 2016 Jul 19. doi: 10.1111/bjd. 14773 (Abstract Link)

Report from the third international consensus meeting to harmonise core outcome measures for atopic eczema / dermatitis clinical trials (HOME)
Chalmers JR1, Schmitt J, Apfelbacher C, Dohil M, Eichenfield LF, Simpson EL, Singh J, Spuls P, Thomas KS, Admani S, Aoki V, Ardeleanu M, Barbarot S, Berger T, Bergman JN, Block J, Borok N, Burton T, Chamlin SL, Deckert S, DeKlotz CC, Graff LB, Hanifin JM, Hebert AA, Humphreys R, Katoh N, Kisa RM, Margolis DJ, Merhand S, Minnillo R, Mizutani H, Nankervis H, Ohya Y, Rodgers P, Schram ME, Stalder JF, Svensson A, Takaoka R, Teper A, Tom WL, von Kobyletzki L, Weisshaar E, Zelt S, Williams HC.
Br J Dermatol. 2014 Dec;171(6):1318-25. doi: 10.1111/bjd.13237 (Abstract Link)

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting
Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H.
Allergy 2012: Sep;67(9):1111-1117; doi 10.1111/j.1398-9995.2012.02874.x (Abstract Link)

Report from the first international consensus meeting (HOME I) 24 July 2010, Munich
Schmitt J, Williams H; HOME Development Group.
Br J Dermatol 2010: 163; 1166-1168 (Abstract Link)

 
HOME Systematic Reviews

Clinical Signs

Assessment of clinical signs of atopic dermatitis: A systematic review and recommendation
Schmitt J, Langan S, Deckert S, Svensson A, von Kobyletzki L, Thomas K, Spuls P, on behalf of the Harmonising Outcome Measures for Atopic Dermatitis (HOME) initiative.
Allergy Clin Immunol 2013 Dec;132(6):1337-47. doi: 10.1016/j.jaci.2013.07.008 (Abstract Link)

Symptoms

Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review
Gerbens LA, Prinsen CA, Chalmers JR, Drucker AM, von Kobyletzki LB, Limpens J, Nankervis H, Svensson A, Terwee CB, Zhang J, Apfelbacher CJ, Spuls PI, Harmonising Outcomes Measures for Eczema (HOME) initiative.
Allergy 2017 Jan;72(1):146-163. doi: 10.1111/all.12959 (Abstract Link)

Reporting of symptoms in randomised controlled trials of atopic eczema treatments: a systematic review
Gerbens LAA, Chalmers JR, Rogers NK, Nankervis H, Spuls PI, on behalf of the Harmonising Outcome Measures for Eczema (HOME) Initiative.
Br J Dermatol. 25 Mar 2016 doi: 10.1111/bjd.14588 (Abstract Link)

Quality of Life 

Measurement properties of quality-of-life measurement instruments for infants, children and adolescents with eczema: a systematic review
Heinl D, Prinsen CA, Sach T, Drucker AM, Ofenloch R, Flohr C, Apfelbacher C. 
Br J Dermatol. 2016 Aug 20 doi: 10.1111/bjd.14966 (Abstract Link)

Eczema Trials: Quality of Life Instruments Used and Their Relation to Patient-reported Outcomes. A Systematic Review
Heinl D, Chalmers J, Nankervis H, Apfelbacher CJ. 
Acta Derm Venereol. 2016 Jun 15;96(5):596-601. doi: 10.2340/00015555-2322. (Abstract Link)

Measurement properties of adult quality-of-life measurement instruments for eczema: protocol for a systematic review
Apfelbacher CJ, Heinl D, Prinsen CA, Deckert S, Chalmers J, Ofenloch R, Humphreys R, Sach T, Chamlin S, Schmitt J.
J Invest Dermatol 2015 Jan;135(1):24-30. doi: 10.1038/jid.2014.320 (Abstract Link)

Measurement properties of adult quality-of-life measurement instruments for eczema: protocol for a systematic review.
Apfelbacher CJ, Heinl D, Prinsen CA, Deckert S, Chalmers J, Ofenloch R, Humphreys R, Sach T, Chamlin S, Schmitt J.
Syst Rev. 2015 Apr 16;4(1):48 (Abstract Link)

Long-term Control 

Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review
Barbarot S, Rogers NK, Abuabara K, Aubert H, Chalmers J, Flohr C, Hanifin J, Naldi L, Margolis DJ, Paul C, Ridd MJ, Anna Schuttelaar ML, Simpson E, Tauber M, Volke A, Weidinger S, Wilkes SR, Wollenberg A, Thomas KS.
J Am Acad Dermatol 2016 Nov; 75(5):1038-1044. doi: 10.1016\jaad.2016.05.043 (Abstract Link)

How are eczema "flares" defined? A systematic review and recommendation for future studies
Langan SM, Schmitt J, Williams HC, Smith S, thomas KS.
Br J Dermatol 2014 Mar;170(3):548-56. doi: 10.1111/bjd.12747 (Abstract Link)

IGA/PGA

A systematic review of Investigator Global Assessment (IGA) in atopic dermatitis (AD) trials: Many options, no standards
Futamura M, Leshem YA, Thomas KS, Nankervis H, Williams HC, Simpson EL.
J Am Acad Dermatol. 2016 Feb;74(2):288-94. doi: 10.1016/j.jaad.2015.09.062. (Abstract Link)

Other

What are the best outcome measurements for atopic eczema? A systematic review
Schmitt J, Langan S, Williams HC and the European Dermato-Epidemiology Network.
J Allergy Clin Immunol 2007 Dec;120(6):1389-98(Abstract Link)

Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring?
Charman C, Chambers C, Williams H.
J Invest Dermatol 2003 Jun;120(6):932-41 (Abstract Link)

Outcome measures of disease severity in atopic eczema
Charman C and Williams HC.
Arch Dermatol 2000; 136:763-769 (Abstract Link)

 
Interpretability (MCID, severity bandings)

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility Trial
Ridd MJ, Gaunt DM, Guy RH, Redmond NM, Garfield K, Hollinghurst S, Ball N, Shaw L, Purdy S, Metcalfe C
Br J Dermatol 2018 Feb 24. doi: 10.1111/bjd.16475 [Epub ahead of print] (Abstract link)

How should minimally important change scores for the Patient-Oriented Eczema Measure be interpreted? A validation using varied methods
Howells L, Ratib S, Chalmers JR, Bradshaw L, Thomas KS, CLOTHES trial team
Br J Dermatol. 2018 Jan 21. doi: 10.1111/bjd.16367 [Epub ahead of print] (Abstract link)

Severity strata for five patient-reported outcomes in adults with atopic dermatitis
Vakharia PP, Chopra R, Sacotte R, Patel N, Immaneni S, White T, Kantor R, Hsu DY, Simpson EL, Silverberg JI.
Br J Dermatol. 2017 Oct 19. doi: 10.1111\bjd. 16078 (Abstract Link)

The Patient-Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
Gaunt DM, Metcalfe C, Ridd M.
Allergy. 2016 Nov;71(11):1620-1625. doi: 10.1111/all.12942. (Abstract Link)

Quality of life measurement and the relationship to disease severity in children with atopic dermatitis in general practice
Valburg RW, Williamson MG, Dirven-Meijer PC, Oranje AP, Van der Wouden JC, Moed H.
Acta Derm Venereol 2011 Mar;91(2):147-51. doi: 10.2340/00015555-1026 (Abstract Link)

What the Eczema Area and Severity Index score tells us about the severity of atopic dermatitis - an interpretability study
Leshem YA, Hajar T, Hanifin JM, Simpson EL.
Br J Dermatol. 2015 May;172(5):1353-7. doi: 10.1111/bjd.13662 (Abstract Link)

EASI, (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference
Schram ME, Spuls PI, Leeflang MM, Lindeboom R, Bos JD, Schmitt J.
Allergy 2012 Jan; 67(1):99-106. doi: 10.1111/j1398-9995.2011.02719.x. (Abstract Link)

 
Other Relevant Publications

A Survey of Delphi Panelists after Core Outcome Set Development Revealed Positive Feedback and Methods to Facilitate Panel Member Participation
Turnbull AE, Dinglas VD, Friedman LA, Chessare CM, Sepulveda KA, Bingham CO, Needham DM
J Clin Epidemiol 2018 Jun 29. pii S0895-4356(17)31285-4. doi: 10.1016/j.clinepi.2018.06.007
(Abstract Link)

TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries
Gerbens LAA, Apfelbacher CJ, Irvine AD, Barbarot S, de Booij RJ, Boyce AE, Deleuran M, Eichenfield LF,
Hof MH, Middelkamp-Hup MA, Roberts A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Williamson PR, Flohr C, Spuls PI, international TREAT Registry Taskforce
Br J Dermatol 2018 May 15. doi: 10.1111/bjd.167414 (Abstract Link)

Do we need another symptom score for childhood eczema?
Hon KL, Kung JSC, Tsang KY, Yu JW, Wong N, Leung TF.
J Dermatolog Treat. 2017 Aug 29:1-22. doi: 10.1080/09546634.2017.1373734 (Abstract Link)

Patient-reported outcome measures in pruritus: A systematic review of measurement properties
Schoch D, Sommer R, Augustin M, Stander S, Blome C.
J Invest Dermatol 2017 Aug 28. pii: S0022-202X(17)31605-6. doi: 10.1016/j.jid.2017.05.020 (Abstract Link)

A comparison study of clinician-rated atopic dermatitis outcome measures for intermediate to dark-skinned patients
Zhao CY, Hao EY, Oh DD, Daniel BS, Martin LK, Su JC, Rodrigues M, Murrell DF.
Br J Dermatol 2017 Apr;176(4):985-992. doi: 10.1111\bjd.15271 (Abstract Link)

What factors are important to patients when  assessing treatment response: An international cross-sectional survey
von Kobyletzki LB, Thomas KS, Schmitt J, Chalmers JR, Deckert S, Aoki V, Weisshaar E, Oja JA, Svensson A. 
Acta Derm Venereol 2017 Jan 4;97(1):86-90. doi: 10.2340/00015555-2480 (Abstract Link)

Eczema symptoms scores: are we getting closer to HOME?
Fedorowicz Z, van Zuuren EJ.
Br J Dermatol 2016 Oct;175(4):667-8 doi: 10.1111/bjd.14786 (Abstract Link)

A pilot comparison study of four clinician-rated atopic dermatitis severity scales.
Zhao CY, Tran AQT, Lazo-Dizon JP, Kim J, Daniel BS, Venugopal SS, Rhodes LM, Law MG, Murrell DF.
Br J Dermatol 2015 Aug;173(2):488-97. doi: 10.1111/bjd.13846 (Abstract Link)

The reliability and validity of outcome measures for atopic dermatitis in patients with pigmented skin: a grey area.
Zhao CY, Wijayanti A, Doria MC, Harris AG, Jain SV, Legaspi KN, Dlova NC, Law MG, Murrell DF.
Int J of Women's Dermatology 1 (2015) 150-154 doi.org/10.1016/j.ijwd.2015.02.002 (Abstract Link)

Reaching clinically relevant outcome measures for new pharmacotherapy and immunotherapy of atopic eczema.
Chalmers J, Deckert S, Schmitt J: Harmonising Outcome Measures for Atopic Dermatitis (HOME) Initiative Executive Board.
Curr Opin Allergy Clin Immunol. 2015 Jun;15(3):227-33. doi: 10.1097/ACI.0000000000000158. (Abstract Link)

Trials are meaningful for clinical decision making only when their endpoints are valid and comparable.
Schmitt J.
Br J Dermatol 2015 May;172(5):1175-7. doi: 10.1111/bjd.13806 (Abstract Link)

Validation of treatment escalation as a definition of atopic eczema flares.
Thomas KS, Stuart B, O'Leary CJ, Schmitt J, Paul C, Williams HC, Langan S.
PLoS One 2015 Apr 21;10(4):e0124770. doi: 10.1371/journal.pone.0124770. (Abstract Link)

Survey of new 2007 and 2011 Cochrane reviews found 37% of prespecified outcomes not reported.
Smith V, Clarke M, Williamson P, Gargon E.
J Clin Epidemiol. 2014 Nov 18. pii: S0895-4356(14)00398-9. doi: 10.1016/j.jclinepi.2014.09.022. (Abstract Link)

Group seeks standardization for what clinical trials must measure.
Keener AB
Nat med 2014 Aug;20(8):798-9. doi: 10.1038/nm0814-798 (Abstract Link)

Choosing important health outcomes for comparative effectiveness research: A systematic review.
Gargon E, Gurung B, medley N, Altman DG, Blazeby JM, Clarke M, Williamson PR.
PLoS One 2014 Jun 16;9(6):e99111. doi: 10.1371/journal.pone.0099111. (Abstract Link)

Developing core outcomes sets: methods for identifying and including patient-reported outcomes (PROs).
Macefield RC, Jacobs M, Korfage IJ, Nicklin J, Whistance RN, Brookes ST, Sprangers MA, Blazeby JM.
Trials 2014 Feb 5;15:49. doi: 10.1186/1745-6215-15-49 (Abstract Link)

Outcome measures in rheumatoid arthritis randomised trials over the last 50 years.
Kirkham JJ, Boers M, Tugwell P, Clarke M, Williamson PR.
Trials 2013 Oct 9;14:324. doi: 10.1186/1745-6215-14-324 (Abstract Link)

Infants' Dermatitis Quality of Life Index (IDQoL): A decade of experience of validations and clinical application.
Basra MKA, Gada V, Ungaro S, Finlay AY, Salek SM.
Br J Dermatol 2013 Oct;169(4):760-8. doi: 10.1111/bjd.12563 (Abstract Link)

Can a core outcome set improve the quality of systematic reviews? A survey of the Co-ordinating Editors of the Cochrane Review Groups.
Kirkham JJ, Gargon E, Clarke M, Williamson PR.
Trials 2013 Jan 22;14:21. doi: 10.1186/1745-6215-14-21 (Abstract Link)

Developing core outcome sets for clinical trials - issues to consider.
Williamson PR, Altman DG, Blazeby JM, Clarke M, Devane D, Gargon E, Tugwell P.
Trials 2012 Aug 6;13:132. doi: 10.1186/1745-6215-13-132 (Abstract Link)

Atopic dermatitis diagnostic criteria and outcome measures for clinical trials: Still a mess.
Flohr C
J Invest Dermatol 2011 Mar;131(3):557-9. doi: 10.1038/jid.2010.36 (Abstract Link)

Measuring atopic eczema severity visually: Which variables are the most important to patients? 
Charman CR, Venn AJ, Williams H.
Arch Dermatol. 2005;141:1146-1151 (Abstract Link)
 

HOME - Harmonising Outcome Measures for Eczema

Centre of Evidence Based Dermatology
University of Nottingham
King's Meadow Campus
Lenton Lane, Nottingham
NG7 2NR, UK

Telephone: +44 115 8232435
Fax: +44 115 8468618
Email: HOME@nottingham.ac.uk