University of Nottingham

HOME IV attendeesAttendees at the HOME IV meeting.

HOME is an global initiative of patients, healthcare professionals, journal editors, regulatory authorities and the pharmaceutical industry. 

Aim: To develop a consensus-based core outcome set (COS) for clinical trials and clinical practice. The core outcome set is the MINIMUM that should be measured in ALL clinical trials.

Foundation of HOME

Despite the high burden of atopic eczema, evidence-based clinical care and decision making is currently HOME logolimited by the use of multiple, unvalidated outcome measures. A systematic review ( Charman et al. 2003), showed that only 27% of the 93 included trials used a published severity scale, with the remainder using modified versions of published scales or un-named scales with no data on validity or reliability. Another systematic review ( Schmitt et al. 2007) showed that most named outcome measurements for eczema have not been tested sufficiently and do not perform adequately in terms of validity, reliability or ease of use. 

HOME was founded in 2008 by Professors Hywel Williams and Jochen Schmitt to bring together the eczema research community to standardise outcome measures by agreeing on a core outcome set to be included in all eczema clinical trials.

Organisational structure


The HOME initiative currently has over 300 members across the globe, with all stakeholder groups represented, including:

  • Healthcare professionals
  • Patients
  • Parents/carers
  • Regulatory bodies
  • Journal editors
  • Pharmaceutical industry

Working Groups

Some members also volunteer to be part of 'working groups' that carry out research needed to enable evidence-based consensus decisions to be made. These groups are:

Clinical signs

Patient reported symptoms

Long term control

Quality of life

Outcomes for routine clinical practice


  • Stakeholder engagement
  • Universal Applicability
  • Ease of use

Executive Committee

  • Eric Simpson,
    USA (Joint Chair)
  • Christian Apfelbacher,
    Germany (Joint Chair)
  • Jochen Schmitt,
  • Hywel Williams,
  • Phyllis Spuls,
    The Netherlands
  • Kim Thomas,
  • Norito Katoh,
  • Yael Leshem,
  • Louise Gerbens,
    The Netherlands
  • Laura Howells,

HOME co-ordination

HOME is co-ordinated by Mike Jacobson. The co-ordinating centre is hosted within the Centre of Evidence-based Dermatology, University of Nottingham, UK

To contact HOME email:


HOME - Harmonising Outcome Measures for Eczema

Centre of Evidence Based Dermatology
University of Nottingham
King's Meadow Campus
Lenton Lane, Nottingham

Telephone: +44 115 8232435
Fax: +44 115 8468618