At the HOME VII meeting, two instruments were recommended for the COS:
- Recap of atopic eczema (RECAP)*
- The Atopic dermatitis control test (ADCT*)
* The ADCT and RECAP were both developed in response to a call at HOME V in 2017 for instruments to be developed to measure eczema control. These instruments and their validation studies will be published in due course and made available via the HOME website.
ADCT and Recap are very similar instruments, and are both newly developed and showed good measurement properties on initial testing. However, it was not possible to select between them until more information is available on how they both perform in trials. Therefore, either can be used for the COS for the time being.
Further validation studies are required, including cross-cultural validation studies and translations, as well as studies to investigate how well a single-item control question performs. If you are interested in carrying out any of this work, please contact email@example.com.
Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review
Barbarot S, Rogers NK, Abuabara K, Aubert H, Chalmers J, Flohr C, Hanifin J, Naldi L, Margolis DJ, Paul C, Ridd MJ, Anna Schuttelaar ML, Simpson E, Tauber M, Volke A, Weidinger S, Wilkes SR, Wollenberg A, Thomas KS.
J Am Acad Dermatol 2016 Nov; 75(5):1038-1044. doi: 10.1016\jaad.2016.05.043 (Abstract Link)
Validation of treatment escalation as a definition of atopic eczema flares.
Thomas KS, Stuart B, O'Leary CJ, Schmitt J, Paul C, Williams HC, Langan S.
PLoS One 2015 Apr 21;10(4):e0124770. doi: 10.1371/journal.pone.0124770. (Abstract Link)
How are eczema "flares" defined? A systematic review and recommendation for future studies
Langan SM, Schmitt J, Williams HC, Smith S, thomas KS.
Br J Dermatol 2014 Mar;170(3):548-56. doi: 10.1111/bjd.12747 (Abstract Link)